“Chitosan-based enzyme-immobilized nanocomposite cryogels with controlled biodegradation profile”

Yazarlar ve Katkıda Bulunanlar

Fatmagul GedikTurdimuhammad Abdullah★Şerife Tozan RüzgarFunda KeteciBuket BakanBunyemin CosutCemil Dizman

Yayıncıdan Oku (DOI)Google Scholar Kaydı Alıntı Yap ve Dışa Aktar (Cite)

Özet ve Araştırma Bulguları (Abstract)

Tissue engineering is a technique that applies temporary biomaterials as scaffolds to facilitate the regeneration of native tissue. A critical challenge is precisely controlling the degradation rate of these scaffolds to match the pace of new tissue formation, ensuring optimal integration and functional recovery. In this study, poly(glycerol carbonate methacrylate) (p(GCMA)) nanoparticles with an average diameter of ∼50 nm were successfully synthesized. These nanoparticles were incorporated into chitosan-based nanocomposite cryogels, which exhibited a macroporous structure with pore sizes of 55–60 μm and a swelling capacity 23 to 35 times of their dry weight. Incorporation of p(GCMA) significantly enhanced their flexibility and thermal stability of nanocomposite cryogels. Importantly, p(GCMA)-containing cryogels effectively immobilized up to 7 mg/g of protease within crosslinked network, allowing for sustained …

Yıllık Atıf Gelişimi & Dinamiği

11 total citations

Toplam Atıf:Atıf Alan 11

Zirve Yılı: 2026 (9 Atıf)

2025

2026

Alıntı Yap ve Dışa Aktar (Cite)

@article{gedik2025chitosan,
  title = {Chitosan-based enzyme-immobilized nanocomposite cryogels with controlled biodegradation profile},
  author = {Fatmagul Gedik, Turdimuhammad Abdullah, Şerife Tozan Rüzgar, Funda Keteci, Buket Bakan, Bunyemin Cosut, Cemil Dizman},
  journal = {International Journal of Biological Macromolecules 318, 145275},
  volume = {318},
  pages = {145275},
  year = {2025},
  publisher = {Elsevier},
  doi = {10.1016/J.IJBIOMAC.2025.145275},
  url = {https://doi.org/10.1016/J.IJBIOMAC.2025.145275},
}